12+green+principles+for+fluorescent+natural+product


 * __12 Green Principles-Fluorescent natural product:__**

> It is better to prevent waste than to treat or clean up waste after it has been created. Yes, the modified experiment makes possible the synthesis of 4-methylumbeliferone using Dowex under solvent free conditions, which reduces the amount of waste. > Synthetic methods should be designed to maximize the incorporation of all materials used in the process into the final product. Yes, the experiment is fairly atom economical with only one equivalent of water and one equivalent of ethanol as the side effects of the final product. > Wherever practicable, synthetic methods should be designed to use and generate substances that possess little or no toxicity to human health and the environment. Yes, the improved experiment avoids the use of dangerous reagents like sulfuric acid and phosphoryl chloride. > Chemical products should be designed to effect their desired function while minimizing their toxicity. Yes, the improved experiment substitutes the use of sulfuric acid and phosphoryl chloride for dowex. > The use of auxiliary substances (e.g., solvents, separation agents, etc.) should be made unnecessary wherever possible and innocuous when used. Yes, the modified experiment is solvent-free. > Energy requirements of chemical processes should be recognized for their environmental and economic impacts and should be minimized. If possible, synthetic methods should be conducted at ambient temperature and pressure. Yes, the experiment requires elevated temperature, but can be effected at lower temperatures minimizing energy consumption and cost. > A raw material or feedstock should be renewable rather than depleting whenever technically and economically practicable. NO > Unnecessary derivatization (use of blocking groups, protection/ deprotection, temporary modification of physical/chemical processes) should be minimized or avoided if possible, because such steps require additional reagents and can generate waste. Yes, the experiment displays simple reactions. > Catalytic reagents (as selective as possible) are superior to stoichiometric reagents. Yes, the waste product is minimized by utilizing a reusable acid catalyst (Dowex). > Chemical products should be designed so that at the end of their function they break down into innocuous degradation products and do not persist in the environment. No > Analytical methodologies need to be further developed to allow for real-time, in-process monitoring and control prior to the formation of hazardous substances. Yes, the improved experiment makes possible the conversion from liquid to solid product, which makes it visually obvious when the reaction is completed. > Substances and the form of a substance used in a chemical process should be chosen to minimize the potential for chemical accidents, including releases, explosions, and fires. Yes, the use of the acid catalyst (Dowex) in the form of nonvolatile beads makes it easy to handle and also a safer experiment. Thanks for writing this and sharing what you learned with us.
 * 1) **Prevention**
 * 1) **Atom Economy**
 * 1) **Less Hazardous Chemical Syntheses**
 * 1) **Designing Safer Chemicals**
 * 1) **Safer Solvents and Auxiliaries**
 * 1) **Design for Energy Efficiency**
 * 1) **Use of Renewable Feedstocks**
 * 1) **Reduce Derivatives**
 * 1) **Catalysis**
 * 1) **Design for Degradation**
 * 1) **Real-time analysis for Pollution Prevention**
 * 1) **Inherently Safer Chemistry for Accident Prevention**
 * Anastas, P. T.; Warner, J. C.; Green Chemistry: Theory and Practice, Oxford University Press: New York, 1998, p.30. By permission of Oxford University Press.