A+Greener+Synthesis+of+Creatine

//__Creatine__// -Nitrogenous organic acid that is synthesized naturally by the human body - Found primarily in skeletal muscles - Fundamental to the energy, metabolism of muscle cells - Currently one of the best-selling sports supplements: Annual U.S. (Sales exceed $400 Million in Powder and pill form)
 * __A Greener Synthesis of Creatine__**


 * Synthesized from Cyanamide and sarcosin**e._ concentrated ammonium hydroxide is used as the catalyst and as the solvent.



__**Materials**__: -0.44g of cyanamide -0.93g of sarcosine -10ml round botton flask - 2ml dilute aqueous ammonia - filter paper

Acute toxicity (oral, dermal, inhalation), categories 1,2,3 Protective Equipment: Eyeshields, Faceshields , Gloves , type P2 (EN 143) respirator cartridges
 * Cyanamide:**

Protective Equipment: Eyeshields, Gloves , type N95 (US) , type P1 (EN143) respirator filter
 * Sarcosine:**

-corrosive and dangerous for the environment -Dispose of this material and its container to hazardous or special waste collection point -Protective Equipment: Faceshields, full-face respirator , Gloves , Goggles , multi-purpose combination respirator cartridge
 * Dilute Aqueous Ammonia:**

Equipment Faceshields, full-face respirator (US) , Gloves , Goggles , multi-purpose combination respirator cartridge (US) , type ABEK (EN14387) respirator filter

__Objectives for this experiment__: The goal is to make reactions safer, more efficient, and more cost effective while minimizing personal and environmental harms. -Reduce generation of dicyanodiamide -Eliminate excess cyanamide -Eliminate use of NaCl -Eliminate use of concentrated NH4OH catalyst

__The Green Aspects__ -Safe Reagents - Eliminate Excess Cyanamide - Reusable Aqueous Solvent - Dilute & Reusable Catalyst - High Purity Product -100% Atom Economy -Minimal Energy Needed IR Spectrum confirmed product identity and purity


 * //__optional/bonus:__//**
 * Product# || Name || Cost$ ||
 * S7672-10MG || [|SARCOSINE BIOXTRA] || 16.10 ||
 * 187364-5G || [|CYANAMIDe] || 18.50 ||
 * 338818-100ML || [|AMMONIUM HYDROXIDE] || 53.30 ||
 * || total cost=====> || 87.90 ||

(These comments refer to the page as it appeared on the Friday it was due, at the time of lab) Most of the issues I asked you to address are here. More explanation of ideas would be helpful; or some additional background about the experiment or the chemistry.